Ammonia → HCID 11258311, compound

HRID 2407032Notes

Reaction equation

HRID 2407032 reaction equation
[N:1]1([C:9]([C@@H:11]([C@H:21]([CH2:34][OH:35])[O:22][CH2:23][P:24]([O:30][CH:31]([CH3:33])[CH3:32])([O:26][CH:27]([CH3:29])[CH3:28])=[O:25])[O:12]C(=O)C2C=CC=CC=2)=[O:10])[CH:8]=[CH:7][C:5](=[O:6])[NH:4][C:2]1=[O:3].N>CO>[N:1]1([C:9]([C@@H:11]([C@H:21]([CH2:34][OH:35])[O:22][CH2:23][P:24]([O:30][CH:31]([CH3:33])[CH3:32])([O:26][CH:27]([CH3:28])[CH3:29])=[O:25])[OH:12])=[O:10])[CH:8]=[CH:7][C:5](=[O:6])[NH:4][C:2]1=[O:3]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 11260778HCID 11260778, compound

Product 1

HCID 11258311HCID 11258311, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 13 (2.03 g, 4.0 mmol) in MeOH saturated with ammonia (300 mL) was stirred at room temperature overnight. The mixture was concentrated, and the residue was purified by column chromatography (CH2Cl2:MeOH=20:1) to give compound 17 (1.52 g, 3.8 mmol) as a white powder in 96% yield which was characterized as follows:

Workup

  1. concentrationThe mixture was concentrated
  2. customthe residue was purified by column chromatography (CH2Cl2:MeOH=20:1)

Sources & evidence

ORD record
ord-0710eaf34f214efdb52f98060add6324
Source dataset
uspto-grants-2014_08
Patent number
US08809520B2

Reaction notes

Loading…