HCID 11258311, compound → HCID 66780829, compound

HRID 2407036Notes

Reaction equation

HRID 2407036 reaction equation
[Na:1].N1C(N)=C2C(N(C([C@@H]([C@H](CO)OCP(O)(O)=O)O)=O)C=N2)=NC=1.[N:25]1([C:33]([C@@H:35]([C@H:37]([CH2:50][OH:51])[O:38][CH2:39][P:40]([O:46]C(C)C)([O:42]C(C)C)=[O:41])[OH:36])=[O:34])[CH:32]=[CH:31][C:29](=[O:30])[NH:28][C:26]1=[O:27]>>[Na:1].[N:25]1([C:33]([C@@H:35]([C@H:37]([CH2:50][OH:51])[O:38][CH2:39][P:40]([OH:42])([OH:46])=[O:41])[OH:36])=[O:34])[CH:32]=[CH:31][C:29](=[O:30])[NH:28][C:26]1=[O:27]

Participants

3

Reactant 2

HCID 11258311HCID 11258311, compoundHCID 66781133HCID 66781133, compound

Product 1

HCID 66780829HCID 66780829, compoundYield 49%

Procedure

This compound was prepared as described for 3a using 17 (200 mg, 0.53 mmol) as a starting material and TBMSBr (200 mL, 2.1 mmol). Compound 3c (93 mg, 0.26 mmol) was obtained as a colorless solid, in 49% yield, which was characterized as follows:

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-5f0580f9b50b448e8f06a16ad803f71e
Source dataset
uspto-grants-2014_08
Patent number
US08809520B2

Reaction notes

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