N-Aminomorpholine → 5-Cyclopentyl-N-morpholino-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxamide

HRID 240704Notes

Reaction equation

HRID 240704 reaction equation
[CH:1]1([C:6]2[CH:7]=[C:8]([C:18]([OH:20])=O)[CH:9]=[N:10][C:11]=2[O:12][CH2:13][C:14]([F:17])([F:16])[F:15])[CH2:5][CH2:4][CH2:3][CH2:2]1.[N:21]1([NH2:27])[CH2:26][CH2:25][O:24][CH2:23][CH2:22]1>>[CH:1]1([C:6]2[CH:7]=[C:8]([C:18]([NH:27][N:21]3[CH2:26][CH2:25][O:24][CH2:23][CH2:22]3)=[O:20])[CH:9]=[N:10][C:11]=2[O:12][CH2:13][C:14]([F:15])([F:16])[F:17])[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

3

Reactant 2

HCID 20315N-AminomorpholineHCID 712941865-Cyclopentyl-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid

Product 1

HCID 712942005-Cyclopentyl-N-morpholino-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxamide

Procedure

The title compound was synthesized in analogy to Example 1 using 5-cyclopentyl-6-(2,2,2-trifluoro-ethoxy)-3-pyridinecarboxylic acid and 4-morpholinamine (CAN 4319-49-7) as starting materials; MS (ESI) 372.1 (M−H)−.

Sources & evidence

ORD record
ord-de7a26e5591941f1a5f6b0f7b98589c9
Source dataset
uspto-grants-2014_02
Patent number
US08648099B2

Reaction notes

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