1-Aminopyrrolidin-2-one → 5-cyclopentyl-N-(2-oxopyrrolidin-1-yl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxamide

HRID 240705Notes

Reaction equation

HRID 240705 reaction equation
[CH:1]1([C:6]2[CH:7]=[C:8]([C:18]([OH:20])=O)[CH:9]=[N:10][C:11]=2[O:12][CH2:13][C:14]([F:17])([F:16])[F:15])[CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:21][N:22]1[CH2:26][CH2:25][CH2:24][C:23]1=[O:27]>>[CH:1]1([C:6]2[CH:7]=[C:8]([C:18]([NH:21][N:22]3[CH2:26][CH2:25][CH2:24][C:23]3=[O:27])=[O:20])[CH:9]=[N:10][C:11]=2[O:12][CH2:13][C:14]([F:15])([F:16])[F:17])[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

3

Reactant 2

HCID 124949741-Aminopyrrolidin-2-oneHCID 712941865-Cyclopentyl-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid

Product 1

HCID 712943175-cyclopentyl-N-(2-oxopyrrolidin-1-yl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxamide

Procedure

The title compound was synthesized in analogy to Example 1 using 5-cyclopentyl-6-(2,2,2-trifluoro-ethoxy)-3-pyridinecarboxylic acid (example 14c) and 1-amino-2-pyrrolidinone (CAN 6837-14-5) as starting materials; MS (EI) 372.1 (M+H)+.

Sources & evidence

ORD record
ord-c3354e4d30fe43639c214b081e3cc6b4
Source dataset
uspto-grants-2014_02
Patent number
US08648099B2

Reaction notes

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