HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-(2-fluorobenzyl)-2H-benzo[b][1,4]thiazin-3(4H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 4H-1,4-Benzothiazin-3-one | HCID 21396 | — |
| Reactant | alpha-Bromo-o-fluorotoluene | HCID 67968 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-(2-fluorobenzyl)-2H-benzo[b][1,4]thiazin-3(4H)-one | HCID 3244415 | 91% |
Reaction Steps
To a mixture of 2H-benzo[b][1,4]thiazin-3(4H)-one (1.0 g, 6.1 mmole) and 1-(bromomethyl)-2- fluorobenzene (0.76 mL, 1.05 equiv) in DMF (10 mL) was added t-BuOK (0.75 g) at 0 ° C. The reaction mixture was warmed to room temperature and stirred overnight. Water was added and the resulted solid was filtrated, rinsed with water, and dried under vacuum to provide 4-(2-fluorobenzyl)-2H-benzo[b][1,4]thiazin-3(4H)-one (1.51 g, 91%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08809530B1 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-54e6983d67f14791b0ea9138aa7a5d63 |
| Source note | uspto-grants-2014_08 |