HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2407065Generated: October 30, 2026
Cesium carbonate → Methyl 1-(4-(methoxycarbonyl)-2-nitrophenyl)piperidine-2-carboxylate
https://huagongshe.com/reaction/2407065
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Methyl pipecolinate | HCID 3463753 | — |
| Reactant | Methyl 4-fluoro-3-nitrobenzoate | HCID 5219721 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Methyl 1-(4-(methoxycarbonyl)-2-nitrophenyl)piperidine-2-carboxylate | HCID 58539009 | 90% |
Reaction Steps
To a mixture of methyl 4-fluoro-3-nitrobenzoate (6.46 g, 32.5 mmole) and methyl piperidine-2-carboxylate (5.57 g, 1.2 equiv) in DMF (80 mL) was added Cs2CO3 (12.7 g). The reaction mixture was stirred at 55° C. overnight. The solid was filtered and the filtrate was evaporated. The residue was recrystallized with EtOAc/Hexane to give Methyl 1-(4-(methoxycarbonyl)-2-nitrophenyl)piperidine-2-carboxylate (9.4 g, 90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08809530B1 |
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| Source dataset | uspto-grants-2014_08 |
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| ORD ID | ord-3f652158cd2a424eacb3dcb50fa55af5 |
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| Source note | uspto-grants-2014_08 |
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