Glyoxal, phenyl-, hydrate → 3-(Methylthio)-5-phenyl-1,2,4-triazine

HRID 2407077Notes

Reaction equation

[NH:1]([C:3]([S:5][CH3:6])=[NH:4])[NH2:2].O.[C:8]1([C:14]([CH:16]=O)=O)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>>[CH3:6][S:5][C:3]1[N:1]=[N:2][CH:16]=[C:14]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:4]=1

Participants

Reactant 2

HCID 12215922Glyoxal, phenyl-, hydrate

HCID 178504051Methyl hydrazinecarbimidothioate

Product 1

HCID 985413-(Methylthio)-5-phenyl-1,2,4-triazineYield 73.2%

Procedure

3-(Methylsulfanyl)-5-phenyl-1,2,4-triazine (2.93 g, 73%) was prepared from methyl hydrazinecarbimidothioate (2.07 g, 19.7 mmol) and phenylglyoxal monohydrate (2.89 g, 19.7 mmol) according to the general procedure of Preparation 2.

Workup

customaccording to the general procedure of Preparation 2

Sources & evidence

ORD record: ord-7a907edb034b498facb81d8e33b31552
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08809525B2

Reaction notes

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