Ammonia → HCID 67362847, compound

HRID 2407090Notes

Reaction equation

HRID 2407090 reaction equation
CS([C:5]1[N:6]=[N:7][CH:8]=[C:9]([C:11]2[CH:16]=[C:15]([F:17])[CH:14]=[C:13]([F:18])[CH:12]=2)[N:10]=1)(=O)=O.[NH3:19]>>[F:18][C:13]1[CH:12]=[C:11]([C:9]2[N:10]=[C:5]([NH2:19])[N:6]=[N:7][CH:8]=2)[CH:16]=[C:15]([F:17])[CH:14]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 67363746HCID 67363746, compound

Product 1

HCID 67362847HCID 67362847, compoundYield 74%

Procedure

5-(3,5-difluorophenyl)-1,2,4-triazin-3-amine (18 g, 74%) was prepared from 3-(methylsulfonyl)-5-(3,5-difluorophenyl)-1,2,4-triazine (31.0 g, 115.0 mmol) and ammonia gas according to the general procedure of Preparation 2.

Workup

  1. customaccording to the general procedure of Preparation 2

Sources & evidence

ORD record
ord-4a2be6a494aa437d820053303588db06
Source dataset
uspto-grants-2014_08
Patent number
US08809525B2

Reaction notes

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