2-Chlorophenylboronic acid → 6-(2-Chlorophenyl)-5-phenyl-1,2,4-triazin-3-amine

HRID 2407104Notes

Reaction equation

HRID 2407104 reaction equation
Br[C:2]1[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[Cl:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1B(O)O>>[Cl:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[C:2]1[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Participants

3

Reactant 2

HCID 27343222-Chlorophenylboronic acidHCID 866761146-Bromo-5-phenyl-1,2,4-triazin-3-amine

Product 1

HCID 673627226-(2-Chlorophenyl)-5-phenyl-1,2,4-triazin-3-amineYield 45.5%

Procedure

6-(2-Chlorophenyl)-5-phenyl-1,2,4-triazin-3-amine (103 mg, 45%) was prepared from 6-bromo-5-phenyl-1,2,4-triazin-3-amine (0.21 g, 0.80 mmol) and 2-chlorophenylboronic acid (0.125 g, 0.80 mmol) according to the general procedure of Example 1.

Sources & evidence

ORD record
ord-ecd54a3057a54fedb9fd369a6f364e4e
Source dataset
uspto-grants-2014_08
Patent number
US08809525B2

Reaction notes

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