(3,4,5-Trifluorophenyl)boronic Acid (contains varying amounts of Anhydride) → HCID 53354626, compound

HRID 2407110Notes

Reaction equation

HRID 2407110 reaction equation
Br[C:2]1[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[F:15][C:16]1[CH:17]=[C:18](B(O)O)[CH:19]=[C:20]([F:23])[C:21]=1[F:22]>>[C:9]1([C:3]2[N:4]=[C:5]([NH2:8])[N:6]=[N:7][C:2]=2[C:18]2[CH:17]=[C:16]([F:15])[C:21]([F:22])=[C:20]([F:23])[CH:19]=2)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Participants

3

Reactant 2

HCID 2734671(3,4,5-Trifluorophenyl)boronic Acid (contains varying amounts of Anhydride)HCID 866761146-Bromo-5-phenyl-1,2,4-triazin-3-amine

Product 1

HCID 53354626HCID 53354626, compoundYield 37%

Procedure

5-Phenyl-6-(3,4,5-trifluorophenyl)-1,2,4-triazin-3-amine (131 mg, 37%) was prepared from 6-bromo-5-phenyl-1,2,4-triazin-3-amine (0.30 g, 1.19 mmol) and 3,4,5-trifluorophenylboronic acid (0.23 g, 1.30 mmol) according to the general procedure of Example 1.

Sources & evidence

ORD record
ord-8f134a5c287142f288f0bea94f817878
Source dataset
uspto-grants-2014_08
Patent number
US08809525B2

Reaction notes

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