(3,5-Difluorophenyl)boronic acid → HCID 53354630, compound

HRID 2407111Notes

Reaction equation

HRID 2407111 reaction equation
Br[C:2]1[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[F:15][C:16]1[CH:17]=[C:18](B(O)O)[CH:19]=[C:20]([F:22])[CH:21]=1>>[F:15][C:16]1[CH:17]=[C:18]([C:2]2[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=2[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:19]=[C:20]([F:22])[CH:21]=1

Participants

3

Reactant 2

HCID 2734338(3,5-Difluorophenyl)boronic acidHCID 866761146-Bromo-5-phenyl-1,2,4-triazin-3-amine

Product 1

HCID 53354630HCID 53354630, compoundYield 47.3%

Procedure

6-(3,5-Difluorophenyl)-5-phenyl-1,2,4-triazin-3-amine (160 mg, 47%) was prepared from 6-bromo-5-phenyl-1,2,4-triazin-3-amine (0.30 g, 1.19 mmol) and 3,5-difluorophenylboronic acid (0.20 g, 1.30 mmol) according to the general procedure of Example 1.

Sources & evidence

ORD record
ord-04fc41d2342743d48468f95853e8efb9
Source dataset
uspto-grants-2014_08
Patent number
US08809525B2

Reaction notes

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