3-Chloro-4-fluorophenylboronic Acid (contains varying amounts of Anhydride) → HCID 53354724, compound

HRID 2407114Notes

Reaction equation

HRID 2407114 reaction equation
Br[C:2]1[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[Cl:15][C:16]1[CH:17]=[C:18](B(O)O)[CH:19]=[CH:20][C:21]=1[F:22]>>[Cl:15][C:16]1[CH:17]=[C:18]([C:2]2[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=2[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:19]=[CH:20][C:21]=1[F:22]

Participants

3

Reactant 2

HCID 27346603-Chloro-4-fluorophenylboronic Acid (contains varying amounts of Anhydride)HCID 866761146-Bromo-5-phenyl-1,2,4-triazin-3-amine

Product 1

HCID 53354724HCID 53354724, compoundYield 29.3%

Procedure

6-(3-Chloro-4-fluorophenyl)-5-phenyl-1,2,4-triazin-3-amine (140 mg, 29%) was prepared from 6-bromo-5-phenyl-1,2,4-triazin-3-amine (0.40 g, 1.59 mmol) and 3-chloro-4-fluorophenylboronic acid (0.33 g, 1.91 mmol) according to the general procedure of Example 1.

Sources & evidence

ORD record
ord-6157afae7ed044f49fedc57a62d806df
Source dataset
uspto-grants-2014_08
Patent number
US08809525B2

Reaction notes

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