3-Fluorophenylboronic acid → HCID 67363642, compound

HRID 2407120Notes

Reaction equation

HRID 2407120 reaction equation
Br[C:2]1[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[F:15][C:16]1[CH:17]=[C:18](B(O)O)[CH:19]=[CH:20][CH:21]=1>>[F:15][C:16]1[CH:21]=[C:20]([C:2]2[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=2[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:19]=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 27339863-Fluorophenylboronic acidHCID 866761146-Bromo-5-phenyl-1,2,4-triazin-3-amine

Product 1

HCID 67363642HCID 67363642, compoundYield 62%

Procedure

6-(3-Fluorophenyl)-5-phenyl-1,2,4-triazin-3-amine (49 mg, 62%) was prepared from 6-bromo-5-phenyl-1,2,4-triazin-3-amine (75 mg, 0.299 mmol) and 3-fluorophenylboronic acid (48.1 mg, 0.344 mmol) according to the general procedure of Example 1.

Sources & evidence

ORD record
ord-0ba336a7983c4226b9c4dd2604c79b2d
Source dataset
uspto-grants-2014_08
Patent number
US08809525B2

Reaction notes

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