(2H-1,3-benzodioxol-5-yl)boronic acid → HCID 67363780, compound

HRID 2407121Notes

Reaction equation

HRID 2407121 reaction equation
Br[C:2]1[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[O:15]1[C:19]2[CH:20]=[CH:21][C:22](B(O)O)=[CH:23][C:18]=2[O:17][CH2:16]1>>[O:15]1[C:19]2[CH:20]=[CH:21][C:22]([C:2]3[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=3[C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=3)=[CH:23][C:18]=2[O:17][CH2:16]1

Participants

3

Reactant 2

HCID 2734371(2H-1,3-benzodioxol-5-yl)boronic acidHCID 866761146-Bromo-5-phenyl-1,2,4-triazin-3-amine

Product 1

HCID 67363780HCID 67363780, compoundYield 62%

Procedure

6-(1,3-Benzodioxol-5-yl)-5-phenyl-1,2,4-triazin-3-amine (54 mg, 62%) was prepared from 6-bromo-5-phenyl-1,2,4-triazin-3-amine (75 mg, 0.299 mmol) and benzo[d][1,3]dioxol-5-ylboronic acid (57.0 mg, 0.344 mmol) according to the general procedure of Example 1.

Sources & evidence

ORD record
ord-4d426f7741f04660b1cd67387ae8b849
Source dataset
uspto-grants-2014_08
Patent number
US08809525B2

Reaction notes

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