(3,5-Dimethoxyphenyl)boronic acid → HCID 53353231, compound

HRID 2407123Notes

Reaction equation

HRID 2407123 reaction equation
Br[C:2]1[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[CH3:15][O:16][C:17]1[CH:18]=[C:19](B(O)O)[CH:20]=[C:21]([O:23][CH3:24])[CH:22]=1>>[CH3:15][O:16][C:17]1[CH:18]=[C:19]([C:2]2[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=2[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:20]=[C:21]([O:23][CH3:24])[CH:22]=1

Participants

3

Reactant 2

HCID 4374257(3,5-Dimethoxyphenyl)boronic acidHCID 866761146-Bromo-5-phenyl-1,2,4-triazin-3-amine

Product 1

HCID 53353231HCID 53353231, compoundYield 60%

Procedure

6-(3,5-Dimethoxyphenyl)-5-phenyl-1,2,4-triazin-3-amine (55 mg, 60%) was prepared from 6-bromo-5-phenyl-1,2,4-triazin-3-amine (75 mg, 0.299 mmol) and 3,5-dimethoxyphenylboronic acid (62.5 mg, 0.344 mmol) according to the general procedure of Example 1.

Sources & evidence

ORD record
ord-76ca3217b4c04fa7a9283a2cece4525a
Source dataset
uspto-grants-2014_08
Patent number
US08809525B2

Reaction notes

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