3-(Dimethylamino)benzeneboronic acid → HCID 53353234, compound

HRID 2407126Notes

Reaction equation

HRID 2407126 reaction equation
Br[C:2]1[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[CH3:15][N:16]([CH3:26])[C:17]1[CH:18]=[C:19](B(O)O)[CH:20]=[CH:21][CH:22]=1>>[CH3:15][N:16]([CH3:26])[C:17]1[CH:22]=[C:21]([C:2]2[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=2[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:20]=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 27625273-(Dimethylamino)benzeneboronic acidHCID 866761146-Bromo-5-phenyl-1,2,4-triazin-3-amine

Product 1

HCID 53353234HCID 53353234, compoundYield 60.8%

Procedure

6-[3-(Dimethylamino)phenyl]-5-phenyl-1,2,4-triazin-3-amine (53 mg, 60%) was prepared from 6-bromo-5-phenyl-1,2,4-triazin-3-amine (75 mg, 0.299 mmol) and 3-(dimethylamino)phenylboronic acid (56.7 mg, 0.344 mmol) according to the general procedure of Example 1.

Sources & evidence

ORD record
ord-688b5da3cb0345f38188dbb4e0d2d7ed
Source dataset
uspto-grants-2014_08
Patent number
US08809525B2

Reaction notes

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