3-(Methanesulfonylamino)phenylboronic acid pinacol ester → HCID 53353236, compound

HRID 2407128Notes

Reaction equation

HRID 2407128 reaction equation
Br[C:2]1[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.CC1(C)C(C)(C)OB([C:23]2[CH:24]=[C:25]([NH:29][S:30]([CH3:33])(=[O:32])=[O:31])[CH:26]=[CH:27][CH:28]=2)O1>>[NH2:8][C:5]1[N:6]=[N:7][C:2]([C:23]2[CH:24]=[C:25]([NH:29][S:30]([CH3:33])(=[O:31])=[O:32])[CH:26]=[CH:27][CH:28]=2)=[C:3]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:4]=1

Participants

3

Reactant 2

HCID 162177153-(Methanesulfonylamino)phenylboronic acid pinacol esterHCID 866761146-Bromo-5-phenyl-1,2,4-triazin-3-amine

Product 1

HCID 53353236HCID 53353236, compoundYield 41.1%

Procedure

N-[3-(3-Amino-5-phenyl-1,2,4-triazin-6-yl)phenyl]methanesulfonamide (42 mg, 41%) was prepared from 6-bromo-5-phenyl-1,2,4-triazin-3-amine (75 mg, 0.299 mmol) and N-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanesulfonamide (102 mg, 0.344 mmol) according to the general procedure of Example 1.

Sources & evidence

ORD record
ord-1b3027111c0f4d0a915573a8e0164dea
Source dataset
uspto-grants-2014_08
Patent number
US08809525B2

Reaction notes

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