3,5-Dichlorophenylboronic acid → HCID 53353326, compound

HRID 2407136Notes

Reaction equation

HRID 2407136 reaction equation
Br[C:2]1[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=1.[Cl:16][C:17]1[CH:18]=[C:19](B(O)O)[CH:20]=[C:21]([Cl:23])[CH:22]=1>>[Cl:16][C:17]1[CH:18]=[C:19]([C:2]2[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=2[C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)[CH:20]=[C:21]([Cl:23])[CH:22]=1

Participants

3

Reactant 2

HCID 27343313,5-Dichlorophenylboronic acidHCID 86676117HCID 86676117, compound

Product 1

HCID 53353326HCID 53353326, compoundYield 27.8%

Procedure

6-(3,5-dichlorophenyl)-5-(4-fluorophenyl)-1,2,4-triazin-3-amine (0.11 g, 17.6%) was prepared from 6-Bromo-5-(4-fluorophenyl)-1,2,4-triazin-3-amine (0.5 g, 1.18 mmol) and 3,5-dichloro phenylboronic acid (0.47 mg, 2.4 mmol) according to the general procedure of Example 1.

Sources & evidence

ORD record
ord-dffabf0f0ce84aae9711b279e6924562
Source dataset
uspto-grants-2014_08
Patent number
US08809525B2

Reaction notes

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