HCID 72219391, compound → HCID 136349863, compound

HRID 2407137Notes

Reaction equation

HRID 2407137 reaction equation
Br[C:2]1[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[CH:15]([O:18][C:19]1[CH:20]=[C:21](B2OC(C)(C)C(C)(C)O2)[CH:22]=[CH:23][C:24]=1[OH:25])([CH3:17])[CH3:16]>>[NH2:8][C:5]1[N:6]=[N:7][C:2]([C:21]2[CH:22]=[CH:23][C:24]([OH:25])=[C:19]([O:18][CH:15]([CH3:17])[CH3:16])[CH:20]=2)=[C:3]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:4]=1

Participants

3

Reactant 2

HCID 72219391HCID 72219391, compoundHCID 866761146-Bromo-5-phenyl-1,2,4-triazin-3-amine

Product 1

HCID 136349863HCID 136349863, compoundYield 18.6%

Procedure

4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-(propan-2-yloxy)phenol (0.450 g, 18%) was prepared from 6-bromo-5-phenyl-1,2,4-triazin-3-amine (1.9 g, 7.52 mmol) and 3-isopropoxy-4-hydroxyphenylboronic acid pinacol ester (2.5 g, 9.02 mmol) according to the general procedure of Example 1.

Sources & evidence

ORD record
ord-a6bc59ed8bab4b3c92b72431d73fc05d
Source dataset
uspto-grants-2014_08
Patent number
US08809525B2

Reaction notes

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