Morpholine → HCID 67363770, compound

HRID 2407141Notes

Reaction equation

HRID 2407141 reaction equation
Br[C:2]1[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[NH:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1>>[N:15]1([C:2]2[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=2[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 866761146-Bromo-5-phenyl-1,2,4-triazin-3-amine

Product 1

HCID 67363770HCID 67363770, compoundYield 24.3%

Procedure

6-(Morpholin-4-yl)-5-phenyl-1,2,4-triazin-3-amine (50 mg, 20%) was prepared from 6-bromo-5-phenyl-1,2,4-triazin-3-amine (0.21 g, 0.80 mmol) and morpholine (0.126 g, 1.44 mmol) according to the general procedure of Example 2.

Sources & evidence

ORD record
ord-077f6b064bae4dad89e71ec3e2b007c6
Source dataset
uspto-grants-2014_08
Patent number
US08809525B2

Reaction notes

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