4-Fluorophenol → HCID 67363589, compound

HRID 2407156Notes

Reaction equation

HRID 2407156 reaction equation
Br[C:2]1[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[F:15][C:16]1[CH:21]=[CH:20][C:19]([OH:22])=[CH:18][CH:17]=1>>[F:15][C:16]1[CH:21]=[CH:20][C:19]([O:22][C:2]2[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=2[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 97324-FluorophenolHCID 866761146-Bromo-5-phenyl-1,2,4-triazin-3-amine

Product 1

HCID 67363589HCID 67363589, compoundYield 8%

Procedure

6-(4-Fluorophenoxy)-5-phenyl-1,2,4-triazin-3-amine (35 mg, 8%) was prepared from 6-bromo-5-phenyl-1,2,4-triazin-3-amine (0.40 g, 1.59 mmol) and 4-fluorophenol (0.36 g, 3.18 mmol) according to the general procedure of Example 3.

Sources & evidence

ORD record
ord-84e6b811457a4cef9d71f6fd15f38b4f
Source dataset
uspto-grants-2014_08
Patent number
US08809525B2

Reaction notes

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