4-Fluoro-3-(trifluoromethyl)phenol → HCID 67363792, compound

HRID 2407159Notes

Reaction equation

HRID 2407159 reaction equation
Br[C:2]1[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[F:15][C:16]1[CH:21]=[CH:20][C:19]([OH:22])=[CH:18][C:17]=1[C:23]([F:26])([F:25])[F:24]>>[F:15][C:16]1[CH:21]=[CH:20][C:19]([O:22][C:2]2[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=2[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:18][C:17]=1[C:23]([F:24])([F:25])[F:26]

Participants

3

Reactant 2

HCID 6018544-Fluoro-3-(trifluoromethyl)phenolHCID 866761146-Bromo-5-phenyl-1,2,4-triazin-3-amine

Product 1

HCID 67363792HCID 67363792, compoundYield 36%

Procedure

6-[4-Fluoro-3-(trifluoromethyl)phenoxy]-5-phenyl-1,2,4-triazin-3-amine (198 mg, 36%) was prepared from 6-bromo-5-phenyl-1,2,4-triazin-3-amine (0.40 g, 1.59 mmol) and 4-fluoro-3-(trifluoromethyl)phenol (0.57 g, 3.18 mmol) according to the general procedure of Example 3.

Sources & evidence

ORD record
ord-056e70bd40464ece872fac14279ec2c7
Source dataset
uspto-grants-2014_08
Patent number
US08809525B2

Reaction notes

Loading…