Cyclopropyltributylstannane → HCID 67364028, compound

HRID 2407164Notes

Reaction equation

FC(F)(F)S(O[C:7]1[CH:12]=[C:11]([Cl:13])[CH:10]=[C:9]([C:14]2[N:19]=[N:18][C:17]([NH2:20])=[N:16][C:15]=2[C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:8]=1)(=O)=O.C([Sn](CCCC)(CCCC)[CH:34]1[CH2:36][CH2:35]1)CCC>>[Cl:13][C:11]1[CH:10]=[C:9]([C:14]2[N:19]=[N:18][C:17]([NH2:20])=[N:16][C:15]=2[C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:8]=[C:7]([CH:34]2[CH2:36][CH2:35]2)[CH:12]=1

Participants

Reactant 2

HCID 10947505Cyclopropyltributylstannane

HCID 86676120HCID 86676120, compound

Product 1

HCID 67364028HCID 67364028, compoundYield 7%

Procedure

6-(3-Chloro-5-cyclopropylphenyl)-5-phenyl-1,2,4-triazin-3-amine (20 mg, 7%) was prepared from 3-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-5-chlorophenyl trifluoromethane-sulfonate (0.40 g, 0.93 mmol) and tri-n-butyl(cyclopropyl) tin (0.37 g, 1.11 mmol) according to the general procedure for Example 4.

Sources & evidence

ORD record: ord-583b938e672b4785a67f43d933374491
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08809525B2

Reaction notes

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