N-Iodosuccinimide → HCID 136333900, compound

HRID 2407169Notes

Reaction equation

HRID 2407169 reaction equation
[NH2:1][C:2]1[N:3]=[N:4][C:5]([C:14]2[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=2)=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:7]=1.[I:21]N1C(=O)CCC1=O>CC(O)=O>[NH2:1][C:2]1[N:3]=[N:4][C:5]([C:14]2[CH:15]=[CH:16][C:17]([OH:20])=[C:18]([I:21])[CH:19]=2)=[C:6]([C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:7]=1

Participants

4

Reactant 2

HCID 120273N-IodosuccinimideHCID 136333901HCID 136333901, compound

Product 1

HCID 136333900HCID 136333900, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

4-(3-Amino-5-phenyl-1,2,4-triazin-6-yl)-phenol (vide supra; 140 mg, 0.530 mmol) was reacted with AcOH (2 mL) and 1-iodopyrrolidine-2,5-dione (119 mg, 0.530 mmol). The mixture was stirred at room temperature for 1 hour then concentrated in vacuo and purified by column chromatography (35 mg, 32%).

Workup

  1. concentrationthen concentrated in vacuo
  2. custompurified by column chromatography (35 mg, 32%)

Sources & evidence

ORD record
ord-2588ca4a4db941669f2d3142bd4b8d21
Source dataset
uspto-grants-2014_08
Patent number
US08809525B2

Reaction notes

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