Azetidine → HCID 53354722, compound

HRID 2407175Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]([NH2:22])[N:11]=[N:12][C:13]=2[C:14]2[CH:19]=[C:18]([CH3:20])[N:17]=[C:16](Cl)[CH:15]=2)=[CH:4][CH:3]=1.[NH:23]1[CH2:26][CH2:25][CH2:24]1>>[N:23]1([C:16]2[CH:15]=[C:14]([C:13]3[N:12]=[N:11][C:10]([NH2:22])=[N:9][C:8]=3[C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=3)[CH:19]=[C:18]([CH3:20])[N:17]=2)[CH2:26][CH2:25][CH2:24]1

Participants

Reactant 2

HCID 10422Azetidine

HCID 86676119azd4635

Product 1

HCID 53354722HCID 53354722, compoundYield 4%

Procedure

6-[2-(azetidin-1-yl)-6-methylpyridin-4-yl]-5-(4-fluorophenyl)-1,2,4-triazin-3-amine (6.0 mg, 4%) was prepared from 5-(4-fluorophenyl)-6-(2-chloro-6-methyl-pyridin-4-yl)-1,2,4-triazin-3-amine (150 mg, 0.48 mmol) and azetidine (136 mg, 0.16 ml, 2.38 mmol) according to the general procedure for Preparation 4a.

Sources & evidence

ORD record: ord-0377584582b3415297dc2879f7dfe562
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08809525B2

Reaction notes

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