5-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid → 5-(4-Chlorophenyl)-N-(4-(2-hydroxyethyl)piperidin-1-yl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxamide

Participants

Reaction Steps

The title compound was synthesized in analogy to Example 1 using 5-(4-chlorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid (CAN 1018782-82-5) and 4-(t-butyl-dimethyl-silanyloxymethyl)-piperidin-1-ylamine trifluoroacetate (1:1) as starting materials; the silyl protecting group was lost during reaction and work-up; LC-MS (UV peak area/ESI) 96.6%, 444.1292 (M+H)+.

Provenance & Evidence