5-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid → 5-(4-Chlorophenyl)-N-(4-methyl-3-oxopiperazin-1-yl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxamide

Participants

Role	Name	HCID	Charge
Reactant	5-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid	HCID 66686971	—
Reactant	4-Amino-1-methylpiperazin-2-one 2,2,2-trifluoroacetate	HCID 71294316	—
Product	5-(4-Chlorophenyl)-N-(4-methyl-3-oxopiperazin-1-yl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxamide	HCID 71294271	—

Reaction Steps

The title compound was synthesized in analogy to Example 1 using 5-(4-chlorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid (CAN 1018782-82-5) and 4-amino-1-methyl-piperazin-2-one trifluoroacetate (1:1) as starting materials; LC-MS (UV peak area/ESI) 94.7%, 443.1084 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08648099B2
Source dataset	uspto-grants-2014_02
ORD ID	ord-cfe206bff23846a9a962ca2d97b55e42
Source note	uspto-grants-2014_02