Borane;tetrahydrofuran → HCID 25174841, compound

HRID 2407245Notes

Reaction equation

HRID 2407245 reaction equation
[O:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[O:4][CH2:3][C@@H:2]1[C:11]([N:13]1[CH2:18][CH2:17][CH2:16][C@H:15]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([O:25][CH3:26])[CH:20]=2)[CH2:14]1)=O.B.C1COCC1>>[O:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[O:4][CH2:3][C@@H:2]1[CH2:11][N:13]1[CH2:18][CH2:17][CH2:16][C@H:15]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([O:25][CH3:26])[CH:20]=2)[CH2:14]1

Participants

3

Reactant 2

HCID 2723981Borane;tetrahydrofuranHCID 66727246HCID 66727246, compound

Product 1

HCID 25174841HCID 25174841, compoundYield 35%

Procedure

(R)-2,3-Dihydrobenzo[1,4]dioxin-2-yl-[(R*)-3-(3-methoxyphenyl)piperidin-1-yl]-methanone (21 mg, 0.059 mmol) was treated with BH3THF according to the above general procedure. Flash chromatography gave 7.0 mg of the title compound.

Sources & evidence

ORD record
ord-473e0bc710c545a1a95e41b5ffe0afad
Source dataset
uspto-grants-2014_08
Patent number
US08809536B2

Reaction notes

Loading…