HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid → 5-(4-Chlorophenyl)-N'-(3-hydroxypropyl)-N'-methyl-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid hydrazide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid | HCID 66686971 | — |
| Reactant | 1-(3-((Tert-butyldimethylsilyl)oxy)propyl)-1-methylhydrazine 2,2,2-trifluoroacetate | HCID 86678102 | — |
| Product | 5-(4-Chlorophenyl)-N'-(3-hydroxypropyl)-N'-methyl-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid hydrazide | HCID 71294133 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 1 using 5-(4-chlorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid (CAN 1018782-82-5) and N-[3-(t-butyl-dimethyl-silanyloxy)-propyl]-N-methyl-hydrazine trifluoroacetate (1:1) as starting materials; the silyl protecting group was lost during reaction and work-up; LC-MS (UV peak area/ESI) 91.5%, 418.1139 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08648099B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-67a76fa1c5764f2880e2800fcbe65970 |
| Source note | uspto-grants-2014_02 |