Allyl bromide → 3-Allyloxymethyl-1-(2,3-dihydrobenzo[1,4]dioxin-2-ylmethyl)-3-methyl-piperidine
Reaction equation
[O:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[O:4][CH2:3][CH:2]1[CH2:11][N:12]1[CH2:17][CH2:16][CH2:15][C:14]([CH2:19][O:20][CH3:21])([CH3:18])[CH2:13]1.[CH2:22](Br)[CH:23]=C>>[CH2:21]([O:20][CH2:19][C:14]1([CH3:18])[CH2:15][CH2:16][CH2:17][N:12]([CH2:11][CH:2]2[O:1][C:6]3[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=3[O:4][CH2:3]2)[CH2:13]1)[CH:22]=[CH2:23]Participants
3
Procedure
The procedure described above for 1-(2,3-dihydrobenzo[1,4]dioxin-2-ylmethyl)-3-methoxymethyl-3-methylpiperidine was repeated except that allyl bromide was used instead of methyl iodide.
Sources & evidence
- ORD record
- ord-7bd68e17683746279f40d7d722289061
- Source dataset
- uspto-grants-2014_08
- Patent number
- US08809536B2
Reaction notes
Loading…