HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 25176118, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Hydroxypiperidine | HCID 23293 | — |
| Reactant | 2-Bromomethyl-1,4-benzodioxane | HCID 98333 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 25176118 | HCID 25176118 | — |
Reaction Conditions
| Temperature | 153 °C |
|---|
Reaction Steps
A mixture of 2-bromomethyl-2,3-dihydrobenzo[1,4]dioxine (2.26 g, 9.88 mmol), piperidin-3-ol (1.0 g, 9.88 mmol) and K2CO3 (6.8 g, 49.43 mmol) in DMF (30 ml) was heated under microwaves at 153° C. for 120 min to give the crude title compound after the usual work-up. The product was purified by column chromatography (DCM/MeOH, 98:2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08809536B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-c5d98e4a764640afa4fc5359829017c9 |
| Source note | uspto-grants-2014_08 |