Methanol → Methyl 4-fluoro-3-nitrobenzoate

Participants

Reaction Steps

4-Fluoro-3-nitrobenzoic acid (3.00 g, 16.2 mmol) was dissolved in methanol 40 mL, and thionyl chloride (3.5 mL, 48.6 mmol) was slowly added thereto at 0° C. The temperature was slowly raised to room temperature, and then stirred under reflux for 1 hour. The solvent was removed by concentration under reduced pressure, to obtain a target compound as an ivory solid (3.12 g, 97%).

Provenance & Evidence