HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Ethyl 3-(2-piperidin-4-yl-ethoxy)-benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | N-Boc-3-(2-piperidin-4-yl-ethoxy)-benzoic acid ethyl ester | HCID 66930054 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Ethyl 3-(2-piperidin-4-yl-ethoxy)-benzoate | HCID 56830235 | 163.9% |
Reaction Steps
TFA (25 ml) was added to a solution of N-Boc-3-(2-piperidin-4-yl-ethoxy)-benzoic acid ethyl ester (8.5 g, 22 mmol) in DCM (100 ml). Stirring overnight followed by evaporation of the solvents afforded 10 g of the title compound as the TFA salt. LC-MS (m/z): 279 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08809540B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-2ad6332d834e407c963f1a4ce3c46737 |
| Source note | uspto-grants-2014_08 |