Hydroxyamine hydrochloride → HCID 178513264, compound

Participants

Reaction Steps

A solution of 2-fluorobiphenyl-4-carbonitrile (1.97 g, 0.01 mol), hydroxylamine hydrochloride (2.09 g, 0.03 mol) and sodium hydrogen carbonate (4.2 g, 0.05 mol) in methanol (50 mL) is heated to reflux for 7 hrs. The reaction mixture is then cooled to room temperature and filtered. The solid is washed with methanol (20 mL). The combined methanol solution is concentrated to dryness to get 2-fluoro-N-hydroxybiphenyl-4-carboxamidine which is used as such for the next step without further purification.

Provenance & Evidence