Potassium Carbonate → HCID 67545855, compound

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Reaction Steps

A mixture of piperidine-1,3,3-tricarboxylic acid 1-tert-butyl 3-benzyl ester (2.85 g 7.85 mmol), potassium carbonate (1.4 g 10 mmol) and bromopinacolone (1.73 mL 17 mmol) in butan-2-one is stirred at room temperature for 6 h. The mixture is washed with water, dried over magnesium sulphate and concentrated under reduced pressure. After purification by column chromatography, the product is crystallized in heptane to give piperidine-1,3,3-tricarboxylic acid 1-tert-butyl 3-benzyl 3-(3,3-dimethyl-2-oxobutyl)ester melting at 60° C.

Provenance & Evidence