Hydrochloric Acid → HCID 131731786, compound

Participants

Reaction Steps

To a solution of piperidine-1,3,3-tricarboxylic acid 1-tert-butyl 3-benzyl 3-(3,3-dimethyl-2-oxobutyl)ester (250 mg 0.54 mmol) in ethyl acetate (3 mL) is added a solution of hydrogen chloride in isopropanol (3 mL 5-6N). The mixture is stirred at room temperature for 3 h, then concentrated under reduced pressure. The solid is triturated in diisopropyl oxide to give piperidine-3,3-dicarboxylic acid 3-benzyl 3-(3,3-dimethyl-2-oxobutyl)ester, hydrochloride melting at 1500.

Provenance & Evidence