HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N-Bis(2-chloroethyl)benzylamine hydrochloride → N-Benzylnormechlorethamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N-Bis(2-chloroethyl)benzylamine hydrochloride | HCID 2777881 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Solvent | Water | HCID 962 | — |
| Product | N-Benzylnormechlorethamine | HCID 5928 | — |
Reaction Steps
A solution of bis(2-chloroethyl)benzylamine, hydrochloride (3.4 g 12.6 mmol) in iced water (10 mL) is made alcaline with a 5N aqueous solution of sodium hydroxyde. Extraction with ethyl acetate, drying of the organic phase over magnesium sulphate and evaporation under reduced pressure affords bis(2-chloroethyl)benzylamine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08809539B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-1b2060055aa745fdaa4aa238aac4cf9f |
| Source note | uspto-grants-2014_08 |