Water → HCID 86646109, compound

Participants

Reaction Conditions

Reaction Steps

Methanesulfonyl chloride (0.157 mL, 0.0020 mol) is added to a stirred solution of {4-[5-(4-cyclohexyl phenyl)-[1,2,4]oxadiazole-3-yl]-phenyl}-methanol (0.45 g, 0.0013 mol) and triethylamine (0.376 mL, 0.0027 mol) in dichloromethane (10 mL) at 5° C. Reaction mixture is stirred at 5° C. for 30 minutes, then treated with demineralized water (10 mL). Dichloromethane layer is separated and aqueous layer is extracted with dichloromethane (2×15 mL). Combined organic layer is dried over sodium sulphate and concentrated under reduced pressure to yield methanesulfonic acid 4-[5-(4-cyclohexyl-phenyl)[1,2,4]oxadiazol-3-yl]-benzyl ester.

Provenance & Evidence