反应详情

To a suspension of thiophosgene (2 mL) in water (5 mL) was added 4-amino-3-chloro-benzonitrile (1 g, 7 mmol) in small portions over a period of 1 h at 25° C. The mixture was extracted with ethyl acetate (3×25 mL). Combined organic phase was washed with brine (1×50 mL), dried (MgSO4) and concentrated to dryness in vacuo. The title compound 3d was obtained as a tan solid (1.3 g, 96% yield).

1. extractionThe mixture was extracted with ethyl acetate (3×25 mL)
2. washCombined organic phase was washed with brine (1×50 mL)
3. dry with materialdried (MgSO4)
4. concentrationconcentrated to dryness in vacuo