Phenethylamine → HCID 3740335, compound

Participants

Reaction Steps

To a stirred solution of 2-phenylethylamine (3.5 mmol, 1 eq) in 40 ml CH2Cl2 were consecutively added, Et3N (0.58 ml, 4.18 mmol, 1.2 eq) and the corresponding sulfonyl chloride (2-naphthalenesulfonyl chloride, 0.87 g, 3.84 mmol, 1.1 eq). The reaction was performed at room temperature during 4 h, until the total consumption of the starting material. Once the solvent was evaporated, the crude mixture was chromatographically purified over Al2O3 using Hexane/AcOEt (70:30) as the eluant. The final yield of the product obtained was 91%, and the purity ≧99% (expressed in % HPLC area).

Provenance & Evidence