HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Iodoxybenzoic acid → 3-Phenyl-1,2-oxazole-5-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Iodoxybenzoic acid | HCID 108794 | — |
| Reactant | (3-Phenyl-5-isoxazolyl)methanol | HCID 2763417 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 3-Phenyl-1,2-oxazole-5-carbaldehyde | HCID 11367267 | 83.2% |
Reaction Steps
A solution of (3-phenylisoxazol-5-yl) methanol (10.0 g) and 2-iodoxybenzoic acid (24.0 g) in ethyl acetate (350 mL) was refluxed overnight. The mixture was cooled to room temperature, filtered and concentrated. The resulting solids were triturated (hexane:diethyl ether=1:1) to obtain the title compound (8.22 g) having the following physical data.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08809538B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-be646b9221064e3ab29bc65e80556eed |
| Source note | uspto-grants-2014_08 |