Diisopropylethylamine → HCID 58504166, compound

Participants

Reaction Conditions

Reaction Steps

2-(Chloromethyl)-5-phenyl-1,3,4-oxadiazole (31 mg, prepared according to the reported preparation in Natero, R.; et al. Synth. Commun. 2004, 34, 2523) was added to a solution of the compound prepared in Example 11 (60 mg) and diisopropylethylamine (0.083 mL) in N,N-dimethylformamide (0.8 mL). The solution was heated to 100° C. overnight. The reaction was cooled to room temperature, diluted with ethyl acetate and washed twice with a saturated aqueous sodium bicarbonate solution. The organic phase was dried over anhydrous magnesium sulfate and concentrated. The residue was purified by column chromatography on silica gel (ethyl acetate:hexane=1:1, then ethyl acetate) to obtain the title compound (36 mg) having the following physical data.

Provenance & Evidence