Hydrochloric Acid → HCID 66989640, compound

Participants

Reaction Steps

2-Bromoethanol (0.012 mL) was added to a mixture of the compound prepared in Example 55 (50 mg) and potassium carbonate (49 mg) in N,N-dimethylformamide (0.8 mL). The mixture was stirred at room temperature overnight, then 50° C. for six hours. The reaction was cooled to room temperature and was adjusted to pH 7 via the addition of aqueous 3% hydrochloric acid. The mixture was extracted twice with ethyl acetate and the organic phases were combined, dried over anhydrous magnesium sulfate and concentrated. The residue was purified by column chromatography on silica gel (methanol:ethyl acetate=1:19) to obtain the title compound (10 mg) having the following physical data.

Provenance & Evidence