3-Phenyl-1,2-oxazole-5-carbaldehyde → HCID 58504190, compound

HRID 2407676Notes

Reaction equation

HRID 2407676 reaction equation
FC(F)(F)C(O)=O.[Cl:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[C:15](=[O:19])[N:14]([CH2:20][CH:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1)[CH2:13][CH2:12]2.[C:27]1([C:33]2[CH:37]=[C:36]([CH:38]=O)[O:35][N:34]=2)[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>>[Cl:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[C:15](=[O:19])[N:14]([CH2:20][CH:21]1[CH2:26][CH2:25][N:24]([CH2:38][C:36]3[O:35][N:34]=[C:33]([C:27]4[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=4)[CH:37]=3)[CH2:23][CH2:22]1)[CH2:13][CH2:12]2

Participants

3

Reactant 2

HCID 113672673-Phenyl-1,2-oxazole-5-carbaldehydeHCID 66989224HCID 66989224, compound

Product 1

HCID 58504190HCID 58504190, compound

Procedure

According to the same procedure described in Example 35, using the compound prepared in Example 62 instead of the compound prepared in Example 11 and the compound prepared in Example 7 instead of 4-phenylthiophene-2-carbaldehyde, the title compound having the following physical data was obtained.

Sources & evidence

ORD record
ord-3c07b15b56574ec58ad4ee44762b5b09
Source dataset
uspto-grants-2014_08
Patent number
US08809538B2

Reaction notes

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