Diisopropylethylamine → HCID 66990394, compound

Participants

Reaction Steps

A solution of 3-phenylisoxazole-5-carboxylic acid (0.075 g) in dichloromethane (1.6 mL) was treated with 1-ethyl-3-(3′-dimethylaminopropyl)carbodiimide hydrochloride (0.084 g), 1-hyroxybenzotriazole hydrate (0.067 g) and diisopropylethylamine (0.21 mL) and stirred for five minutes. The product prepared in Example 11 (0.17 g) was added and the mixture was stirred at room temperature overnight. The mixture was partitioned between 1 N hydrochloric acid and dichloromethane. The organic phase was dried over anhydrous magnesium sulfate and concentrated. The residue was purified by column chromatography on silica gel (dichloromethane:methanol=9:1) to obtain the title compound (0.077 g) having the following physical data.

Provenance & Evidence