反应详情

温度

50 °C

4-Fluorophenyl acetylene (525 mg, 4.37 mmol) was added to 1,1,1-tributyl-N,N-dimethylstannanamine (1.46 g, 4.37 mmol), and the mixture was stirred in a sealed vial at 50° C. for 2 hours. The mixture was cooled to ambient temperature, and the vial was stirred unsealed for 10 minutes. Benzyl azide (850 μL, 6.80 mmol) was added, and the vial was resealed and heated to 130° C. overnight. The mixture was purified by silica gel chromatography eluting with a gradient of 5-35% ethyl acetate in hexanes to afford the title compound. MS (ESI+) m/z 544.4 (M+H)+.

1. temperatureThe mixture was cooled to ambient temperature
2. stirringthe vial was stirred unsealed for 10 minutes
3. temperatureheated to 130° C. overnight
4. customThe mixture was purified by silica gel chromatography
5. washeluting with a gradient of 5-35% ethyl acetate in hexanes