Potassium Carbonate → HCID 58503993, compound

Participants

Reaction Steps

The compound prepared in Example 120 (0.500 g), tert-butyl 2-bromoethylcarbamate (0.704 g) and potassium carbonate (1.16 g) were suspended in acetonitrile (20 mL) and heated at reflux overnight. Another 0.5 equivalents of tert-butyl 2-bromoethylcarbamate was added and the reaction mixture heated at reflux overnight again. The reaction mixture was cooled to room temperature and partitioned between saturated aqueous sodium bicarbonate and ethyl acetate. The organics were washed with brine, dried over magnesium sulfate, filtered and concentrated under reduced pressure to afford the crude material, which was purified by flash column chromatography to furnish the title compound (0.624 g) having the following physical data.

Provenance & Evidence