Sodium borohydride → HCID 58504204, compound

Participants

Reaction Steps

The compound prepared in Example 121 (0.620 g) was suspended in methanol (30 mL) and sodium borohydride (0.088 g) was added portion-wise to the stirred reaction mixture at room temperature. Excess sodium borohydride was added portion-wise to the reaction mixture and the system heated at reflux overnight. The reaction mixture was cooled to room temperature and concentrated under reduced pressure. The solids were partitioned between saturated aqueous ammonium chloride and ethyl acetate. The organics were washed with brine, dried, magnesium sulfate and concentrated under reduced pressure to afford the crude material, which was purified by flash column chromatography (pre-absorbed to silica) (eluant: 50-75% ethyl acetate/hexane 0.5% triethylamine) to furnish the title compound (0.253 g) having the following physical data.

Provenance & Evidence