反应详情

Ethyl 4-methyl-2-phenylthiazole-5-carboxylate (5.00 g), N-bromosuccinimide (3.78 g) and benzoyl peroxide (0.49 g) were suspended in carbon tetrachloride (50 mL) and heated at reflux overnight. The reaction mixture was cooled to room temperature and partitioned between dichloromethane and saturated aqueous sodium bicarbonate. The combined organics were dried over magnesium sulfate and concentrated under reduced pressure to afford the crude title compound (6.60 g), which was used without further purification possessing the following physical data.

1. temperatureheated
2. temperatureat reflux overnight
3. custompartitioned between dichloromethane and saturated aqueous sodium bicarbonate
4. dry with materialThe combined organics were dried over magnesium sulfate
5. concentrationconcentrated under reduced pressure