Methyl iodide → HCID 58503945, compound

Participants

Reaction Conditions

Reaction Steps

The compound prepared in Example 130 (0.204 g) was suspended in N,N-dimethyl formamide (4 mL) and cooled to 0° C. Potassium carbonate (0.279 g) was added and then iodomethane (0.069 mL). The reaction mixture was stirred at 0° C. for 30 minutes and then warmed to room temperature and stirred at room temperature for further 1 hour. The reaction mixture was diluted with ethyl acetate and washed sequentially with sodium bicarbonate aqueous solution and brine. The organics were dried over magnesium sulfate, filtered and concentrated under reduced pressure to afford the crude material, which was purified by flash column chromatography to furnish the title compound (0.130 g) having the following physical data.

Provenance & Evidence